At a glance
Receptor
Amylin / Calcitonin
Molecular Weight
3958.5 Da
Reported Half-Life
~6 days
Storage
-20°C lyophilized
Molecular Formula
C174H277N53O53
CAS Number
1415456-99-3
Purity
≥99%
Reconstitution
BAC water
Overview
Metabolic peptides are studied in vitro and in animal models for their effects on glucose handling, insulin signaling, appetite regulation, and energy expenditure. They typically engage incretin or amylin receptor pathways.
Cagrilintide is studied for its activity at Amylin / Calcitonin, with a reported half-life of ~7 days. The compound is supplied as a lyophilized powder and reconstituted with bac water prior to use in laboratory research.
Mechanism of Action
GPCR-driven cAMP / PKA cascade with downstream effects on insulin secretion, gastric emptying, and central appetite circuits.
In published in-vitro work, Cagrilintide engages Amylin alongside related receptor subtypes to initiate downstream signaling. The reported half-life of ~7 days informs typical dosing intervals in experimental protocols.
Research Applications
- Glucose tolerance and insulin sensitivity assays
- Receptor binding and cAMP signaling experiments
- Body composition and metabolic rate studies in animal models
- Comparative pharmacology against reference incretins
Handling & Reconstitution
Reference guidance for laboratory handling.
- Storage: -20°C lyophilized. Avoid repeated freeze-thaw cycles.
- Reconstitution: BAC water. Add diluent slowly down the side of the vial; gentle swirl, do not shake.
- Stability: Once reconstituted, store at 2–8°C and use within 14–28 days depending on peptide stability.
- Working solution: Calculate target concentration before reconstitution. Our calculator can help.
Quality & Verification
- Every batch of Cagrilintide we ship is third-party tested by an ISO-accredited lab. Each order arrives with a batch-matched Certificate of Analysis showing HPLC purity (≥99%), mass spectrometry confirmation of 3958.5 Da, and endotoxin / bioburden screening where applicable.
Related Entries
Incretin dual-agonist receptor research
GLP-1 receptor pharmacology
Amylin receptor research
Lipolysis pathway research
Shop Cagrilintide
≥99% purity · third-party tested · ships from the USA