At a glance
Receptor
GLP-1R
Molecular Weight
4113.6 Da
Reported Half-Life
~7 days
Storage
-20°C lyophilized
Molecular Formula
C187H291N45O59
CAS Number
910463-68-2
Purity
≥99%
Reconstitution
BAC water
Overview
Metabolic peptides are studied in vitro and in animal models for their effects on glucose handling, insulin signaling, appetite regulation, and energy expenditure. They typically engage incretin or amylin receptor pathways.
Semaglutide is studied for its activity at GLP-1R, with a reported half-life of ~7 days. The compound is supplied as a lyophilized powder and reconstituted with bac water prior to use in laboratory research.
Mechanism of Action
GPCR-driven cAMP / PKA cascade with downstream effects on insulin secretion, gastric emptying, and central appetite circuits.
In published in-vitro work, Semaglutide engages GLP-1R to initiate downstream signaling. The reported half-life of ~7 days informs typical dosing intervals in experimental protocols.
Research Applications
- Glucose tolerance and insulin sensitivity assays
- Receptor binding and cAMP signaling experiments
- Body composition and metabolic rate studies in animal models
- Comparative pharmacology against reference incretins
Handling & Reconstitution
Reference guidance for laboratory handling.
- Storage: -20°C lyophilized. Avoid repeated freeze-thaw cycles.
- Reconstitution: BAC water. Add diluent slowly down the side of the vial; gentle swirl, do not shake.
- Stability: Once reconstituted, store at 2–8°C and use within 14–28 days depending on peptide stability.
- Working solution: Calculate target concentration before reconstitution. Our calculator can help.
Quality & Verification
- Every batch of Semaglutide we ship is third-party tested by an ISO-accredited lab. Each order arrives with a batch-matched Certificate of Analysis showing HPLC purity (≥99%), mass spectrometry confirmation of 4113.6 Da, and endotoxin / bioburden screening where applicable.
Related Entries
GLP-1 receptor pharmacology
Triple incretin agonist research
Amylin receptor research
Lipolysis pathway research
Shop Semaglutide
≥99% purity · third-party tested · ships from the USA