At a glance
Receptor
GHRH-R
Molecular Weight
5135.9 Da
Reported Half-Life
~30 min
Storage
-20°C lyophilized
Molecular Formula
C221H366N72O67S
CAS Number
218949-48-5
Purity
≥99%
Reconstitution
BAC water
Overview
Growth-factor peptides are studied for their effects on the GH/IGF-1 axis, satellite cell activation, and skeletal muscle hypertrophy pathways. Most act as GHRH analogs, ghrelin receptor agonists, or IGF-1 variants.
Tesamorelin is studied for its activity at GHRH-R, with a reported half-life of ~30 min. The compound is supplied as a lyophilized powder and reconstituted with bac water prior to use in laboratory research.
Mechanism of Action
GHRH-R / GHS-R1a → adenylate cyclase / phospholipase C, downstream JAK/STAT5 via GH/IGF-1.
In published in-vitro work, Tesamorelin engages GHRH-R to initiate downstream signaling. The reported half-life of ~30 min informs typical dosing intervals in experimental protocols.
Research Applications
- GH pulse and IGF-1 measurement studies
- Myoblast proliferation and differentiation assays
- Body composition and lean mass studies in animal models
- Receptor binding and downstream signaling experiments
Handling & Reconstitution
Reference guidance for laboratory handling.
- Storage: -20°C lyophilized. Avoid repeated freeze-thaw cycles.
- Reconstitution: BAC water. Add diluent slowly down the side of the vial; gentle swirl, do not shake.
- Stability: Once reconstituted, store at 2–8°C and use within 14–28 days depending on peptide stability.
- Working solution: Calculate target concentration before reconstitution. Our calculator can help.
Quality & Verification
- Every batch of Tesamorelin we ship is third-party tested by an ISO-accredited lab. Each order arrives with a batch-matched Certificate of Analysis showing HPLC purity (≥99%), mass spectrometry confirmation of 5135.9 Da, and endotoxin / bioburden screening where applicable.
Related Entries
Senolytic research
Antioxidant pathway research
NAD metabolism research
Mitochondrial protection research
Shop Tesamorelin
≥99% purity · third-party tested · ships from the USA