At a glance
Sequence
LKKTETQ (TB4 17-23)
Molecular Weight
C212H350N56O78S
CAS Number
77591-33-4
Purity
≥99%
Receptor
Actin-binding (G-actin)
Molecular Weight
4963.5 Da
Reported Half-Life
~2-3 hr
Storage
-20°C lyophilized
Reconstitution
BAC water
Overview
Tissue-repair peptides are investigated for their roles in angiogenesis, fibroblast activity, extracellular matrix remodeling, and inflammation resolution. Many derive from naturally-occurring fragments of larger repair proteins.
TB-500 is studied for its activity at Actin-binding (G-actin), with a reported half-life of ~2-3 hr. The compound is supplied as a lyophilized powder and reconstituted with bac water prior to use in laboratory research.
Mechanism of Action
VEGF / NO signaling, actin polymerization, and downregulation of pro-inflammatory transcription factors.
In published in-vitro work, TB-500 engages Actin-binding (G-actin) to initiate downstream signaling. The reported half-life of ~2-3 hr informs typical dosing intervals in experimental protocols.
Research Applications
- Wound healing and cell migration assays
- Tendon and ligament repair models
- Angiogenesis (HUVEC, CAM) experiments
- NF-κB and cytokine modulation studies
Handling & Reconstitution
Reference guidance for laboratory handling.
- Storage: -20°C lyophilized. Avoid repeated freeze-thaw cycles.
- Reconstitution: BAC water. Add diluent slowly down the side of the vial; gentle swirl, do not shake.
- Stability: Once reconstituted, store at 2–8°C and use within 14–28 days depending on peptide stability.
- Working solution: Calculate target concentration before reconstitution. Our calculator can help.
Quality & Verification
- Every batch of TB-500 we ship is third-party tested by an ISO-accredited lab. Each order arrives with a batch-matched Certificate of Analysis showing HPLC purity (≥99%), mass spectrometry confirmation of 4963.5 Da, and endotoxin / bioburden screening where applicable.
Related Entries
Senolytic research
Antioxidant pathway research
NAD metabolism research
Mitochondrial protection research
Shop TB-500
≥99% purity · third-party tested · ships from the USA