At a glance
Sequence
MEHFPGP
Molecular Weight
C39H54N10O10S
CAS Number
80714-61-0
Purity
≥99%
Receptor
BDNF / nootropic
Molecular Weight
854.95 Da
Reported Half-Life
~hours (intranasal)
Storage
-20°C lyophilized
Reconstitution
BAC water
Overview
Receptor-targeted peptides bind specific G-protein-coupled or nuclear receptors to probe pharmacology in neuropsychiatric, dermatological, or sleep-related pathways.
Semax is studied for its activity at BDNF / nootropic, with a reported half-life of ~hours (intranasal). The compound is supplied as a lyophilized powder and reconstituted with bac water prior to use in laboratory research.
Mechanism of Action
GPCR-mediated cAMP / Ca²⁺ signaling specific to the target receptor family.
In published in-vitro work, Semax engages BDNF alongside related receptor subtypes to initiate downstream signaling. The reported half-life of ~hours (intranasal) informs typical dosing intervals in experimental protocols.
Research Applications
- Receptor binding affinity assays
- Behavioral pharmacology in animal models
- Intranasal delivery and CNS penetration studies
- Comparative selectivity against close analogs
Handling & Reconstitution
Reference guidance for laboratory handling.
- Storage: -20°C lyophilized. Avoid repeated freeze-thaw cycles.
- Reconstitution: BAC water. Add diluent slowly down the side of the vial; gentle swirl, do not shake.
- Stability: Once reconstituted, store at 2–8°C and use within 14–28 days depending on peptide stability.
- Working solution: Calculate target concentration before reconstitution. Our calculator can help.
Quality & Verification
- Every batch of Semax we ship is third-party tested by an ISO-accredited lab. Each order arrives with a batch-matched Certificate of Analysis showing HPLC purity (≥99%), mass spectrometry confirmation of 854.95 Da, and endotoxin / bioburden screening where applicable.
Related Entries
Sleep peptide research
Non-selective melanocortin research
Melanocortin receptor research
Neuropeptide anxiolytic research
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≥99% purity · third-party tested · ships from the USA