At a glance
Receptor
Sirtuin cofactor / redox
Molecular Weight
663.4 Da
Reported Half-Life
~minutes
Storage
-20°C lyophilized
Molecular Formula
C21H27N7O14P2
CAS Number
53-84-9
Purity
≥99%
Reconstitution
BAC water
Overview
Longevity peptides are studied for their effects on mitochondrial function, telomere biology, cellular senescence, and redox balance. They often modulate sirtuin activity, cardiolipin integrity, or senescent-cell clearance.
NAD+ is studied for its activity at Sirtuin cofactor / redox, with a reported half-life of ~minutes. The compound is supplied as a lyophilized powder and reconstituted with bac water prior to use in laboratory research.
Mechanism of Action
Sirtuin / AMPK activation, mitochondrial membrane stabilization, or FOXO/p53 disruption depending on target.
In published in-vitro work, NAD+ engages Sirtuin cofactor alongside related receptor subtypes to initiate downstream signaling. The reported half-life of ~minutes informs typical dosing intervals in experimental protocols.
Research Applications
- Mitochondrial respiration (Seahorse) experiments
- Telomere length and telomerase assays
- Senescent cell clearance models
- Oxidative stress and glutathione recycling studies
Handling & Reconstitution
Reference guidance for laboratory handling.
- Storage: -20°C lyophilized. Avoid repeated freeze-thaw cycles.
- Reconstitution: BAC water. Add diluent slowly down the side of the vial; gentle swirl, do not shake.
- Stability: Once reconstituted, store at 2–8°C and use within 14–28 days depending on peptide stability.
- Working solution: Calculate target concentration before reconstitution. Our calculator can help.
Quality & Verification
- Every batch of NAD+ we ship is third-party tested by an ISO-accredited lab. Each order arrives with a batch-matched Certificate of Analysis showing HPLC purity (≥99%), mass spectrometry confirmation of 663.4 Da, and endotoxin / bioburden screening where applicable.
Related Entries
Senolytic research
Antioxidant pathway research
Mitochondrial protection research
Telomere & pineal research
Shop NAD+
≥99% purity · third-party tested · ships from the USA