Epitalon: Telomere and Pineal Research in In Vitro Models

Epitalon (also spelled Epithalon, Epithalamin) is a synthetic tetrapeptide originally derived from extracts of the pineal gland. Its sequence — Ala-Glu-Asp-Gly — is one of the shortest bioactive peptides in research literature.

In vitro studies have examined Epitalon's reported effects on telomerase activity in human somatic cell lines, with several published papers measuring telomere length over extended culture passages. Comparative studies frequently pair Epitalon with other "longevity" peptides such as Thymalin or FOXO4-DRI.

Because the peptide is so short, mass-spec confirmation is essential. Sub-99% purity in a 4-residue peptide can produce confounding signal at higher concentrations.

Reconstitute with bacteriostatic water; store working stocks at 2–8°C and use within two weeks. For in vitro research use only.